TNF-alpha, recombinant human protein

$100.00
In stock
Catalog
P1005
Bulk Inquiry

Description

Tumor Necrosis Factor-α (TNF-α) is a potent cytokine mainly produced by macrophages, and other cells, including CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFa plays an important role in inflammation, immune modulation, antitumor activity and hematopoiesis. There are two receptors of TNF-a, TNFR1 and TNFR2. TNF-a is primarily expressed as a 233aa-long transmembrane protein. Then, the soluble 17kDa TNF-a is cleaved with TNF-a converting enzyme (TACE) and forms mature and stable homotrimers. 

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Uniprot number

P01375

Expressed in

E.coli

Molecular Weight

17.4 kDa

Related biological data

 

Storage

Store  at -20°C

Appearance

Lyophilized powder

Formulation

Lyophilized from a solution of 3 mM Tris, pH 8.0.

Purity

 ≥95%, determined by SDS-PAGE

Note

For laboratory research only. Not for clinical applications.

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