Amyloid beta peptide (1-42aa)
Amyloid beta (Aβ or Abeta) peptides derive from the amyloid precursor protein (APP). Ab is yielded by cleaving the APP with beta secretase and gamma secretase. The peptide 36-43aa is the main component of amyloid plaques found in the brains crucially involved in Alzheimer’s disease. The peptides can aggregate to form various soluble oligomers. It is believed that in certain conditions, misfolded oligomers (seed) can induce other Ab molecules to aggregate to misfolded insoluble form, and then lead to a prion infection.