TNF-alpha, recombinant human protein
Description
Tumor Necrosis Factor-α (TNF-α) is a potent cytokine mainly produced by macrophages, and other cells, including CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFa plays an important role in inflammation, immune modulation, antitumor activity and hematopoiesis. There are two receptors of TNF-a, TNFR1 and TNFR2. TNF-a is primarily expressed as a 233aa-long transmembrane protein. Then, the soluble 17kDa TNF-a is cleaved with TNF-a converting enzyme (TACE) and forms mature and stable homotrimers.
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Uniprot number |
P01375 |
|
Expressed in |
E.coli |
|
Molecular Weight |
17.4 kDa |
|
Related biological data |
 |
|
Storage |
Store at -20°C |
|
Appearance |
Lyophilized powder |
|
Formulation |
Lyophilized from a solution of 3 mM Tris, pH 8.0. |
|
Purity |
≥95%, determined by SDS-PAGE |
|
Note |
For laboratory research only. Not for clinical applications. |
